منابع مشابه
Guanidine Structure and Hypoglycemia
By a series of structural changes, Frank, Nothmann, and Wagner (1) developed synthalin, the most powerful hypoglycemic synthetic product known today. The details of their researches are not available. The increased hypoglycemic activity of agmatine over guanidine offered the first clue as to the nature of the groups which were productive of hypoglycemic activity. It may be gathered from the rec...
متن کاملNaked Eye DNA detection: synthesis, characterization and DNA binding studies of a novel azo-guanidine.
A novel class of azo-guanidine compounds is introduced in this article. The novel compound 2-(2-hydroxyphenyl)-1-(phenylamino)-3-(phenylimino)guanidine (AG) was synthesized and well characterized by using different analytical instrumental techniques like elemental analysis, FTIR, (1)H and (13)C NMR, UV-Visible spectroscopy and cyclic voltammetry. The new compound was found interacting with DNA ...
متن کاملCircular dichroism studies suggest that TAR RNA changes conformation upon specific binding of arginine or guanidine.
Short basic peptides from the HIV Tat protein bind specifically to a bulge region in TAR RNA, with a single arginine residue providing the only sequence-specific contact. The free amino acid arginine also binds specifically to TAR. Previous circular dichroism (CD) experiments suggested that peptide binding induces a conformational change in TAR. Here we confirm this observation using single arg...
متن کاملDeoxynucleic Guanidine/Peptide Nucleic Acid Chimeras: Synthesis, Binding and Invasion Studies with DNA
A fully automated solid-phase synthetic procedure for incorporation of positively charged guanidinium linkages into otherwise neutral PNA sequences has been employed. These DNG/PNA chimeras form [(DNG/ PNA)2‚DNA] triplexes upon binding to single strand or duplex DNA (with accompanying D-loop for the latter). The [(DNG/PNA)2‚DNA] triplexes of DNG/PNA T10, with DNA dA10, are more stable than DNA‚...
متن کاملStudies in the Metabolic Changes Induced by Administration of Guanidine Bases
Paton and Findlay (I) confirmed the results of former workers in a series of critical investigations, in which they found that true tetany developed only after complete parathyroidectomy and that when one external parathyroid was left with its blood supply intact, no symptoms, or at most transient tremors, appear. Many hypotheses concerning the cause of tetany have been proposed, especially fro...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1928
ISSN: 0306-3283
DOI: 10.1042/bj0220937